Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.77 |
| ▸ | LCK | P06239 | 2/20 | 0.77 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.77 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.58 |
| ▸ | MTOR | P42345 | 9/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6478410 | 0.93 | KDR (0.80) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL6478730 | 0.93 | KDR (0.77) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214616 | 0.87 | KDR (0.84) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214680 | 0.84 | LCK (0.76) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214609 | 0.83 | KDR (0.87) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214615 | 0.82 | KDR (0.85) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214730 | 0.82 | KDR (0.82) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL6480335 | 0.81 | LCK (0.71) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214727 | 0.81 | KDR (0.71) | KDRLCKMAPK14PIK3CAMTOR | |
| SCHEMBL14214612 | 0.81 | KDR (0.82) | KDRLCKMAPK14PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6864255-B2 | Substituted triazinyl amide derivatives and methods of use | AMGEN INC. (US) | 2005-03-08 | — | — | US | disclosed |
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |