Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.82 |
| ▸ | LCK | P06239 | 3/20 | 0.82 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.82 |
| ▸ | IGF1R | P08069 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.55 |
| ▸ | MTOR | P42345 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480335 | 0.88 | LCK (0.71) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL14214609 | 0.87 | KDR (0.87) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL14214615 | 0.87 | KDR (0.85) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL14214616 | 0.86 | KDR (0.84) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL14214612 | 0.85 | KDR (0.82) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL14214680 | 0.85 | LCK (0.76) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL6489956 | 0.84 | KDR (0.81) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL14214614 | 0.84 | KDR (0.78) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL6478952 | 0.84 | KDR (0.74) | KDRLCKMAPK14IGF1RPIK3CA | |
| SCHEMBL6480028 | 0.82 | KDR (0.77) | KDRLCKMAPK14IGF1RPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |