Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.56 |
| ▸ | MTOR | P42345 | 5/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214728 | 0.90 | MKNK1 (0.53) | SCN9APIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL6479199 | 0.86 | PIK3CA (0.52) | SCN9APIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL14380902 | 0.84 | MKNK1 (0.55) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14214627 | 0.81 | AURKA (0.48) | PIK3CAMTOR | |
| SCHEMBL6478730 | 0.80 | KDR (0.77) | SCN9APIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL3244139 | 0.80 | PIK3CA (0.55) | SCN9APIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL14214617 | 0.78 | KDR (0.53) | SCN9APIK3CAMTOR | |
| SCHEMBL6479848 | 0.77 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14214626 | 0.76 | CDK1 (0.47) | PIK3CAMTOR | |
| SCHEMBL14214621 | 0.76 | KDR (0.57) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |