Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380901 | 0.89 | MKNK1 (0.69) | MKNK1MKNK2PIK3CGROCK1AURKA | |
| SCHEMBL14380903 | 0.86 | AURKA (0.52) | MKNK1MKNK2PIK3CAMTORAURKA | |
| SCHEMBL14214732 | 0.84 | SCN9A (0.59) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL14380899 | 0.82 | MKNK1 (0.80) | MKNK1MKNK2 | |
| SCHEMBL14380908 | 0.76 | MAPK8 (0.47) | MKNK1MKNK2 | |
| SCHEMBL14380858 | 0.75 | KDR (0.56) | PIK3CAPIK3CBPIK3CG | |
| SCHEMBL5039680 | 0.75 | AURKA (0.62) | ROCK1AURKA | |
| SCHEMBL14214728 | 0.74 | MKNK1 (0.53) | MKNK1MKNK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4726882 | 0.74 | AURKA (0.64) | ROCK1AURKA | |
| SCHEMBL4903688 | 0.73 | MAPK8 (0.63) | PIK3CGAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282504-B2 | Kinase inhibitors | AMGEN INC. (US) | 2007-10-16 | — | — | US | disclosed |
| US-7282504-B2 | Kinase inhibitors | AMGEN INC. (US) | 2007-10-16 | — | — | US | disclosed |