Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214939 | 0.83 | OPRM1 (0.51) | HDAC9SIGMAR1SMN1; SMN2PRCP | |
| SCHEMBL10107447 | 0.76 | GAA (0.38) | ALDH1A1SIGMAR1CYP3A4GAAMAPT | |
| SCHEMBL10107574 | 0.76 | GAA (0.38) | ALDH1A1SIGMAR1CYP3A4GAAMAPT | |
| SCHEMBL1754817 | 0.76 | GAA (0.38) | ALDH1A1SIGMAR1CYP3A4GAAMAPT | |
| SCHEMBL10107443 | 0.76 | GAA (0.38) | ALDH1A1SIGMAR1CYP3A4GAAMAPT | |
| SCHEMBL1753729 | 0.76 | GAA (0.38) | ALDH1A1SIGMAR1CYP3A4GAAMAPT | |
| SCHEMBL1654890 | 0.76 | ALDH1A1 (0.43) | HDAC9ALDH1A1CYP3A4GAAMAPT | |
| SCHEMBL14214917 | 0.74 | HDAC9 (0.57) | HDAC9SIGMAR1CYP3A4TSHRMEN1 | |
| SCHEMBL1754829 | 0.72 | CA1 (0.39) | ALDH1A1SIGMAR1GAAHTTMAPT | |
| SCHEMBL1753440 | 0.72 | CA1 (0.39) | ALDH1A1SIGMAR1GAAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008049806-A1 | PIPERIDINE OR PIPERAZINE SUBSTITUTED TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID MTP INHIBITING COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-02 | — | — | WO | disclosed |