Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427424 | 0.82 | USP30 (0.52) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL12426663 | 0.77 | HTR4 (0.56) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL13575604 | 0.76 | USP30 (0.58) | PDE4BPDE4APDE4CPDE4DUSP30 | |
| SCHEMBL10143889 | 0.76 | USP30 (0.58) | PDE4BPDE4APDE4CPDE4DUSP30 | |
| SCHEMBL3546076 | 0.76 | HDAC4 (0.52) | PDE4BPDE4APDE4CPDE4DUSP30 | |
| SCHEMBL15753507 | 0.75 | ALDH1A1 (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4542499 | 0.75 | ALDH1A1 (0.52) | PDE4BHDAC1HDAC2STS | |
| SCHEMBL28608081 | 0.74 | STS (0.54) | PDE4BPDE4APDE4CPDE4DSTS | |
| SCHEMBL3314495 | 0.73 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DHDAC1 | |
| SCHEMBL12426326 | 0.73 | USP30 (0.46) | PDE4BPDE4APDE4CPDE4DUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008050096-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-02 | — | — | WO | disclosed |