Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207328 | 0.76 | PPARA (0.58) | KMT2ASMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL13958437 | 0.76 | CA12 (0.58) | KMT2ASMN1; SMN2MAPTHDAC3HDAC1 | |
| SCHEMBL9141936 | 0.75 | HPGD (0.54) | POLBHPGD | |
| SCHEMBL14316384 | 0.74 | PTGER4 (0.48) | KMT2ASMN1; SMN2RAB9AMEN1ALDH1A1 | |
| SCHEMBL8380931 | 0.73 | PPARA (0.51) | KMT2ASMN1; SMN2RAB9AALDH1A1TP53 | |
| SCHEMBL8380930 | 0.73 | PPARA (0.51) | KMT2ASMN1; SMN2RAB9AALDH1A1TP53 | |
| SCHEMBL8782823 | 0.73 | ABCG2 (0.62) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL641622 | 0.73 | CA12 (0.58) | KMT2ASMN1; SMN2MAPTHDAC3HDAC1 | |
| SCHEMBL142092 | 0.73 | ABCG2 (0.62) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL19244469 | 0.73 | ABCG2 (0.62) | KMT2ARAB9AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125478-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125478-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | HDAC2, HDAC1, BAZ2A | KMT2A 323/4885SMN1; SMN2 4413/4885RAB9A 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.