Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8380930 | 1.00 | PPARA (0.51) | PPARAKMT2ASMN1; SMN2KDM1ACA12 | |
| SCHEMBL8381015 | 0.87 | PPARA (0.52) | PPARAKMT2ASMN1; SMN2GSK3BBACE1 | |
| SCHEMBL8381018 | 0.87 | PPARA (0.52) | PPARAKMT2ASMN1; SMN2GSK3BBACE1 | |
| SCHEMBL5207328 | 0.85 | PPARA (0.58) | PPARAKMT2ASMN1; SMN2KDM1ACA12 | |
| SCHEMBL8380557 | 0.81 | SMN1; SMN2 (0.62) | KMT2ASMN1; SMN2MAPTRAB9AALDH1A1 | |
| SCHEMBL8213995 | 0.81 | AKR1B10 (0.61) | PPARAKMT2ASMN1; SMN2GSK3BBACE1 | |
| SCHEMBL8782823 | 0.79 | ABCG2 (0.62) | PPARASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL13958437 | 0.79 | CA12 (0.58) | PPARAKMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL142092 | 0.79 | ABCG2 (0.62) | PPARASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL19244469 | 0.79 | ABCG2 (0.62) | KMT2ACA12CA1CA2TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874436-A | EFFECTIVE IN INHIBITING THE ACTION OF A BACTERIAL HISTIDINE PROTEIN KINASE; USEFUL AGAINST ANTIBIOTIC RESISTANT ORGANISMS | DEMERS JAMES P (US) | 1999-02-23 | — | — | US | disclosed |
| WO-1997048676-A1 | TRIPHENYLALKYL ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-12-24 | — | — | WO | disclosed |
| US-5643950-A | INHIBITORS OF A BACTERIAL HISTIDINE PROTEIN KINASE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |