Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.57 |
| ▸ | ZAP70 | P43403 | 14/20 | 0.57 |
| ▸ | SRC | P12931 | 12/20 | 0.57 |
| ▸ | CDK2 | P24941 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14378974 | 0.87 | SYK (0.73) | SYKZAP70SRCCDK2 | |
| SCHEMBL14216016 | 0.83 | ZAP70 (0.72) | SYKZAP70SRCCDK2 | |
| SCHEMBL14216178 | 0.80 | SYK (0.70) | SYKZAP70SRCCDK2 | |
| SCHEMBL4385809 | 0.77 | AURKA (0.58) | SYKZAP70SRCCDK2 | |
| SCHEMBL14216177 | 0.76 | SYK (0.78) | SYKZAP70SRCCDK2 | |
| SCHEMBL14216126 | 0.72 | SYK (1.00) | SYKZAP70SRCCDK2 | |
| SCHEMBL14216150 | 0.72 | ZAP70 (0.66) | SYKZAP70SRCCDK2 | |
| SCHEMBL14378999 | 0.72 | CDK2 (0.64) | SYKZAP70SRCCDK2 | |
| SCHEMBL14216130 | 0.72 | SYK (0.73) | SYKZAP70SRCCDK2 | |
| SCHEMBL4383661 | 0.71 | CDK2 (0.53) | SYKZAP70SRCCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |