Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 14/20 | 0.72 |
| ▸ | SYK | P43405 | 14/20 | 0.72 |
| ▸ | SRC | P12931 | 12/20 | 0.72 |
| ▸ | CDK2 | P24941 | 10/20 | 0.72 |
| ▸ | CDK4 | P11802 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14378974 | 0.89 | SYK (0.73) | ZAP70SYKSRCCDK2KDR | |
| SCHEMBL14378999 | 0.85 | CDK2 (0.64) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216122 | 0.84 | ZAP70 (1.00) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216149 | 0.84 | SYK (0.68) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216049 | 0.84 | SYK (0.76) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216308 | 0.84 | ZAP70 (0.65) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL4391357 | 0.84 | CDK2 (0.68) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216034 | 0.84 | SYK (0.76) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216043 | 0.84 | SYK (0.83) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216015 | 0.83 | SYK (0.57) | ZAP70SYKSRCCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |