Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536585 | 0.82 | MAPK1 (0.44) | MAPK1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL1536503 | 0.81 | PDE1B (0.48) | MAPK1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL25075454 | 0.80 | CA1 (0.40) | LMNAMAPTDYRK1AMAOACA1 | |
| SCHEMBL3061434 | 0.79 | MAPK1 (0.42) | MAPK1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL9623295 | 0.79 | ESR1 (0.55) | MAPK1CYP3A4MAPTESR1ESR2 | |
| SCHEMBL15647812 | 0.76 | HIF1A (0.43) | MAPK1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL4005339 | 0.73 | LMNA (0.46) | MAPK1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL26928380 | 0.73 | LMNA (0.46) | MAPK1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL15647758 | 0.72 | KMT2A (0.46) | MAPK1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL12266517 | 0.72 | LMNA (0.60) | MAPK1LMNACYP3A4MAPTAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089385-B1 | INHIBITORS OF HEPATITIS C VIRUS | BRISTOL MYERS SQUIBB CO (US) | 2016-01-06 | — | — | EP | disclosed |
| EP-1951743-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-03-19 | — | — | EP | disclosed |
| WO-2008057873-A2 | INHIBITORS OF HEPATITIS C VIRUS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-15 | — | — | WO | disclosed |