Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | STAT3 | P40763 | 5/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3993933 | 0.90 | MAPT (0.64) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3931598 | 0.85 | MAPT (0.69) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3920972 | 0.85 | MEN1 (0.70) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3931603 | 0.84 | MAPT (0.68) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3423881 | 0.84 | MAPT (0.56) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3919729 | 0.83 | ALDH1A1 (0.65) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL4507527 | 0.82 | MAPT (0.62) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3432855 | 0.82 | MEN1 (0.58) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3423868 | 0.82 | ALDH1A1 (0.60) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3921486 | 0.81 | MAPT (0.62) | MAPTLMNAGAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756118-B1 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | NYCOMED GMBH (DE) | 2008-05-28 | — | — | EP | disclosed |