Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ME2 | P23368 | 1/20 | 0.34 |
| ▸ | ME1 | P48163 | 1/20 | 0.34 |
| ▸ | ME3 | Q16798 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265989 | 0.72 | POLB (0.41) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL1265990 | 0.72 | POLB (0.41) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL1266878 | 0.67 | ALDH1A1 (0.47) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL1266880 | 0.67 | ALDH1A1 (0.47) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL372772 | 0.62 | CHRNA7 (0.54) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL10518177 | 0.61 | MEN1 (0.47) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL10518172 | 0.61 | MEN1 (0.47) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL10518184 | 0.61 | MEN1 (0.47) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL4456981 | 0.61 | KMT2A (0.89) | RAB9ANPC1SMN1; SMN2MAPTHPGD | |
| SCHEMBL16599448 | 0.61 | KMT2A (0.89) | RAB9ANPC1SMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046581-A2 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE COMPOUNDS AND USE THEREOF IN MEDICAMENTS | Grünenthal GmbH (DE) | 2008-04-24 | — | — | WO | disclosed |