Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229617 | 0.86 | KMT2A (0.50) | ALDH1A1MAPTGFERLMNAL3MBTL1 | |
| SCHEMBL8773412 | 0.80 | HTT (0.68) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL8270033 | 0.80 | HDAC3 (0.53) | ALDH1A1MAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL2902945 | 0.80 | KMT2A (0.79) | ALDH1A1MAPTGFERLMNAL3MBTL1 | |
| SCHEMBL12956151 | 0.78 | LMNA (0.60) | ALDH1A1MAPTGFERLMNAL3MBTL1 | |
| SCHEMBL12392897 | 0.77 | HTT (0.56) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL11620459 | 0.77 | MAPT (0.61) | ALDH1A1MAPTGFERLMNAL3MBTL1 | |
| SCHEMBL22411255 | 0.75 | MEN1 (0.56) | ALDH1A1MAPTGFERLMNAL3MBTL1 | |
| SCHEMBL30873828 | 0.75 | MEN1 (0.56) | ALDH1A1MAPTGFERLMNAL3MBTL1 | |
| SCHEMBL13368241 | 0.74 | ALDH1A1 (0.59) | ALDH1A1MAPTGFERLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368467-B2 | Calcium channel modulators 2-(alkyl or (hetero)arylalkylthio)-imidazoles and S-oxides thereof; angina, hypertension, congestive heart failure, myocardial ischemia, arrhythmia, diabetes, urinary incontinence, stroke, pain, brain injury, or neuronal disorders | WYETH (US) | 2008-05-06 | — | — | US | disclosed |