SCHEMBL14219357

SCHEMBL14219357

C[C@@H](CC1=CCC=C(c2ccc(-c3ccc(Cl)cc3)cc2)C=C1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.36
FYN P06241 1/20 0.35
CYP1A2 P05177 1/20 0.35
SLC6A2 P23975 2/20 0.33
SLC6A4 P31645 2/20 0.33
SLC6A3 Q01959 2/20 0.33
OPRK1 P41145 1/20 0.33
CHRM2 P08172 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
BCL2 P10415 1/20 0.33
CHRM1 P11229 1/20 0.33
DRD1 P21728 1/20 0.33
TBXA2R P21731 1/20 0.33
ADRA1A P35348 1/20 0.33
DRD3 P35462 1/20 0.33
KCNH2 Q12809 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33
EP300 Q09472 2/20 0.33
MAOA P21397 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4624068 0.73 TAAR1 (0.42) MAOAMAOBNISCHCYP2D6TAAR1
SCHEMBL14220013 0.69 SLC6A2 (0.44) CNR1CYP1A2SLC6A2SLC6A3MAOB
SCHEMBL14219903 0.69 SLC6A2 (0.44) CNR1CYP1A2SLC6A2SLC6A3MAOB
SCHEMBL14219567 0.69 SLC6A2 (0.44) CNR1CYP1A2SLC6A2SLC6A3MAOB
SCHEMBL4603712 0.67 SLC6A2 (0.53) CNR1CYP1A2SLC6A2SLC6A4SLC6A3
SCHEMBL4603704 0.67 SLC6A2 (0.53) CNR1CYP1A2SLC6A2SLC6A4SLC6A3
Ammonia Solution, Strong SCHEMBL8867131 0.66 SLC6A2 (0.52) CNR1CYP1A2SLC6A2SLC6A4SLC6A3
SCHEMBL29758290 0.64 ESR1 (0.52) SLC6A2SLC6A4SLC6A3HTR1AMAOA
SCHEMBL18676704 0.63 RIPK1 (0.53) SLC6A2SLC6A4SLC6A3CHRM2HTR1A
Ammonia Solution, Strong SCHEMBL5305670 0.63 ESR1 (0.50) SLC6A2SLC6A4SLC6A3HTR1AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1650285-B1 Liquid crystal composition containing an optically active compound and liquid crystal electro-optical element SEIMI CHEM KK (JP) 2008-04-30 EP disclosed