SCHEMBL14219459

SCHEMBL14219459

C[C@H](Cc1ccc(C2CCC(c3ccc(F)c(F)c3)CC2)cc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.38
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
KDM1A O60341 1/20 0.36
CCR5 P51681 2/20 0.35
ADRA1A P35348 2/20 0.34
DRD2 P14416 1/20 0.34
ADRA1D P25100 1/20 0.34
ADRA1B P35368 1/20 0.34
APP P05067 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14219988 0.90 HCRTR1 (0.34) PDPK1
SCHEMBL14219321 0.90 ESR1 (0.36) ESR1ESR2APP
SCHEMBL14219401 0.90 ESR1 (0.36) ESR1ESR2APP
SCHEMBL14220026 0.89 PPARG (0.38) ESR1ESR2
SCHEMBL14219468 0.89 PPARG (0.38) ESR1ESR2
SCHEMBL14220027 0.88 ESR1 (0.36) ESR1ESR2APP
SCHEMBL14219392 0.87 ESR1 (0.35) ESR1ESR2CCR5APP
SCHEMBL14219406 0.87 ESR1 (0.41) ESR1ESR2APP
SCHEMBL14219956 0.87 HCRTR1 (0.38) PDPK1KDM1ACCR5
SCHEMBL14219926 0.87 HCRTR1 (0.38) PDPK1KDM1ACCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1650285-B1 Liquid crystal composition containing an optically active compound and liquid crystal electro-optical element SEIMI CHEM KK (JP) 2008-04-30 EP disclosed