SCHEMBL14219465

SCHEMBL14219465

C[C@H](Cc1c(F)cc(C2CCC(c3ccc(Cl)cc3)CC2)cc1F)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.39
PRCP P42785 2/20 0.39
CCR1 P32246 15/20 0.38
KCNH2 Q12809 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
USP2 O75604 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
CYP1A2 P05177 1/20 0.36
MAPT P10636 1/20 0.36
CYP2C9 P11712 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
HIF1A Q16665 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14220025 1.00 ADRB2 (0.39) ADRB2PRCPCCR1KCNH2MEN1
SCHEMBL14219462 0.90 CCR1 (0.39) ADRB2CCR1
SCHEMBL14219968 0.87 CCR1 (0.36) ADRB2PRCPCCR1MEN1KMT2A
SCHEMBL14219574 0.87 CCR1 (0.36) ADRB2PRCPCCR1MEN1KMT2A
SCHEMBL14219946 0.87 HAT1 (0.34) CCR1MEN1KMT2A
SCHEMBL14219394 0.84 GRIA1 (0.40)
SCHEMBL14219454 0.84 SPHK1 (0.37) CCR1
SCHEMBL14219911 0.84 SPHK1 (0.37) CCR1
SCHEMBL14219915 0.83 MEN1 (0.39) MEN1KMT2ALMNA
SCHEMBL14219398 0.83 MEN1 (0.39) MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1650285-B1 Liquid crystal composition containing an optically active compound and liquid crystal electro-optical element SEIMI CHEM KK (JP) 2008-04-30 EP disclosed