SCHEMBL14219912

SCHEMBL14219912

CCOc1ccc(C2CCC(c3ccc(C[C@@H](C)c4ccccc4)cc3)CC2)cc1F

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.45
PTGDR2 Q9Y5Y4 7/20 0.38
CCR5 P51681 3/20 0.36
FAAH O00519 1/20 0.36
ADRB1 P08588 1/20 0.34
ADRB3 P13945 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TACR1 P25103 1/20 0.34
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
POLB P06746 1/20 0.33
PRMT5 O14744 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14219391 1.00 KDM1A (0.45) KDM1APTGDR2CCR5FAAHADRB1
SCHEMBL14219984 0.91 KDM1A (0.40) KDM1APTGDR2CCR5FAAHPOLB
SCHEMBL14219600 0.91 KDM1A (0.40) KDM1APTGDR2CCR5FAAHPOLB
SCHEMBL14219958 0.89 KDM1A (0.38) KDM1APTGDR2CCR5FAAHPOLB
SCHEMBL14219927 0.89 KDM1A (0.38) KDM1APTGDR2CCR5FAAHPOLB
SCHEMBL14220021 0.89 KDM1A (0.34) KDM1APTGDR2CCR5L3MBTL1SMN1; SMN2
SCHEMBL14219459 0.85 PDPK1 (0.38) KDM1ACCR5
SCHEMBL14220023 0.82 MEN1 (0.49) L3MBTL1
SCHEMBL14219321 0.82 ESR1 (0.36)
SCHEMBL14219401 0.82 ESR1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1650285-B1 Liquid crystal composition containing an optically active compound and liquid crystal electro-optical element SEIMI CHEM KK (JP) 2008-04-30 EP disclosed