Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14222999 | 0.95 | HCRTR1 (0.35) | CFTRHCRTR1HCRTR2KDM4EUSP2 | |
| SCHEMBL12796193 | 0.86 | ALDH1A1 (0.41) | CFTRHCRTR1HCRTR2KDM4EUSP2 | |
| SCHEMBL14223156 | 0.80 | KDM4E (0.36) | CFTRKDM4EUSP2HTTHSD17B10 | |
| SCHEMBL14222339 | 0.79 | ALDH1A1 (0.37) | CFTRKDM4EUSP2HTTHSD17B10 | |
| SCHEMBL14222756 | 0.77 | ALDH1A1 (0.40) | CFTRKDM4EUSP2HTTHSD17B10 | |
| SCHEMBL12796187 | 0.75 | GAA (0.44) | KDM4EUSP2HTTHSD17B10TP53 | |
| SCHEMBL14222750 | 0.74 | TP53 (0.45) | CFTRKDM4EUSP2HTTHSD17B10 | |
| SCHEMBL14222426 | 0.73 | KDM4E (0.48) | CFTRKDM4EUSP2HTTHSD17B10 | |
| SCHEMBL14222746 | 0.72 | TP53 (0.44) | CFTRKDM4EUSP2HTTHSD17B10 | |
| SCHEMBL12796210 | 0.71 | ALDH1A1 (0.39) | HCRTR1HCRTR2KDM4EUSP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039520-A2 | FUSED RING COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2008-04-03 | — | — | WO | disclosed |