Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | PPIA | P62937 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13926143 | 0.85 | ALDH1A1 (0.56) | POLBALDH1A1TP53HTTPPIA | |
| SCHEMBL14019877 | 0.80 | PPIA (0.57) | POLBALDH1A1TP53PPIALMNA | |
| SCHEMBL16672173 | 0.78 | POLB (0.55) | POLBALDH1A1LMNAKMT2AKDM4E | |
| SCHEMBL27422735 | 0.77 | ALDH1A1 (0.63) | ALDH1A1PPIALMNARAB9ANPC1 | |
| SCHEMBL27478482 | 0.76 | ALDH1A1 (0.62) | ALDH1A1PPIALMNARAB9ANPC1 | |
| SCHEMBL26345373 | 0.75 | LMNA (0.54) | ALDH1A1PPIALMNARAB9ANPC1 | |
| SCHEMBL21776096 | 0.75 | ALDH1A1 (0.56) | ALDH1A1PPIALMNARAB9ANPC1 | |
| SCHEMBL28557434 | 0.75 | ALDH1A1 (0.60) | ALDH1A1LMNARAB9ANPC1MAPK1 | |
| SCHEMBL171506 | 0.74 | PPIA (0.50) | ALDH1A1PPIALMNARAB9ANPC1 | |
| SCHEMBL8676974 | 0.73 | ALDH1A1 (0.54) | ALDH1A1LMNARAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046216-A1 | KINASE INHIBITORS AND USES THEREOF | METHYLGENE, INC. (CA) | 2008-04-24 | — | — | WO | disclosed |