Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | CTSG | P08311 | 2/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
| ▸ | CMA1 | P23946 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224123 | 0.88 | MAPT (0.48) | SMN1; SMN2NPC1RAB9AKMT2ALMNA | |
| SCHEMBL14224125 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AEPHX2GPR139 | |
| SCHEMBL14223781 | 0.84 | MTNR1A (0.53) | NPC1RAB9AKMT2A | |
| SCHEMBL27712528 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AEPHX2GPR139 | |
| SCHEMBL28399130 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AEPHX2GPR139 | |
| SCHEMBL5709362 | 0.79 | NPC1 (0.67) | SMN1; SMN2NPC1RAB9AEPHX2GPR139 | |
| SCHEMBL2481230 | 0.79 | NPC1 (0.67) | SMN1; SMN2NPC1RAB9AEPHX2GPR139 | |
| SCHEMBL19668706 | 0.77 | NPC1 (0.52) | SMN1; SMN2NPC1RAB9AEPHX2GPR139 | |
| SCHEMBL31530566 | 0.77 | NPC1 (0.73) | SMN1; SMN2NPC1RAB9AEPHX2GPR139 | |
| SCHEMBL29111412 | 0.75 | NPC1 (0.52) | SMN1; SMN2NPC1RAB9AGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7355037-B2 | Thermolabile hydroxyl protecting groups and methods of use | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-04-08 | — | — | US | disclosed |