Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2481230 | 1.00 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2GPR139EPHX2 | |
| SCHEMBL8162012 | 0.90 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2EPHX2MAPT | |
| SCHEMBL6196126 | 0.89 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2GPR139EPHX2 | |
| SCHEMBL6196129 | 0.89 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2GPR139EPHX2 | |
| SCHEMBL3641032 | 0.86 | FFAR1 (0.56) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL3057455 | 0.86 | TACR1 (0.60) | NPC1RAB9ASMN1; SMN2GPR139MAPT | |
| SCHEMBL3641034 | 0.86 | FFAR1 (0.56) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL2304580 | 0.85 | KMT2A (0.55) | NPC1RAB9ASMN1; SMN2GPR139GAA | |
| SCHEMBL1924441 | 0.84 | KCNA3 (0.65) | NPC1RAB9ASMN1; SMN2GPR139EPHX2 | |
| SCHEMBL4530460 | 0.83 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2GPR139KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727790-A1 | PHENYLAMINOETHANOL DERIVATIVES AS BETA2 RECEPTOR AGONISTS | Pfizer Limited (GB) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005090288-A1 | PHENYLAMINOETHANOL DERIVATES AS BETA2 RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |