Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.43 |
| ▸ | ITGAV | P06756 | 5/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501348 | 0.89 | ITGB3 (0.48) | ITGB3ITGAVITGA2BDPP4MAPK1 | |
| SCHEMBL8474796 | 0.89 | ITGB3 (0.44) | ITGB3ITGAVITGA2BDPP4MAPK1 | |
| SCHEMBL8487967 | 0.87 | ITGB3 (0.42) | ITGB3ITGAVITGA2BDPP4MAPK1 | |
| SCHEMBL14224073 | 0.74 | ITGB3 (0.43) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL14195949 | 0.71 | ITGB3 (0.48) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL4805768 | 0.71 | ITGB3 (0.48) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL14195945 | 0.71 | ITGB3 (0.48) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL13344630 | 0.71 | ITGB3 (0.54) | ITGB3ITGAVITGA2BDPP4MAPK1 | |
| SCHEMBL8487183 | 0.70 | ITGB3 (0.42) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL14195948 | 0.70 | ITGB3 (0.42) | ITGB3ITGAVITGA2BDPP4ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351711-B2 | Tricyclic indanyls as integrin inhibitors | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2008-04-01 | — | — | US | disclosed |