Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.43 |
| ▸ | ITGAV | P06756 | 10/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14195945 | 0.90 | ITGB3 (0.48) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL14195949 | 0.90 | ITGB3 (0.48) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL4805768 | 0.90 | ITGB3 (0.48) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL8487183 | 0.88 | ITGB3 (0.42) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL14195948 | 0.88 | ITGB3 (0.42) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL14195947 | 0.88 | ITGB3 (0.42) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL14224072 | 0.74 | ITGB3 (0.43) | ITGB3ITGAVITGA2BDPP4ITGB5 | |
| SCHEMBL13344630 | 0.73 | ITGB3 (0.54) | ITGB3ITGAVITGA2BDPP4GRIN2B | |
| SCHEMBL8486338 | 0.71 | NPC1 (0.36) | GRIN2BNOS2 | |
| SCHEMBL8501348 | 0.70 | ITGB3 (0.48) | ITGB3ITGAVITGA2BDPP4ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351711-B2 | Tricyclic indanyls as integrin inhibitors | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2008-04-01 | — | — | US | disclosed |