Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 3/20 | 0.49 |
| ▸ | KDM1A | O60341 | 3/20 | 0.48 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7827978 | 1.00 | CCR5 (0.50) | CCR5RORCKDM1AFUCA1S1PR1 | |
| SCHEMBL7817702 | 1.00 | CCR5 (0.50) | CCR5RORCKDM1AFUCA1S1PR1 | |
| SCHEMBL4105592 | 1.00 | CCR5 (0.50) | CCR5RORCKDM1AFUCA1S1PR1 | |
| SCHEMBL5266055 | 1.00 | CCR5 (0.50) | CCR5RORCKDM1AFUCA1S1PR1 | |
| SCHEMBL5274170 | 0.87 | CCR5 (0.57) | CCR5RORCFUCA1DRD2DRD3 | |
| SCHEMBL5236286 | 0.87 | CCR5 (0.57) | CCR5RORCFUCA1DRD2DRD3 | |
| SCHEMBL1714572 | 0.85 | SIGMAR1 (0.47) | CCR5RORCFUCA1S1PR1S1PR5 | |
| SCHEMBL7868518 | 0.85 | CCR5 (0.42) | CCR5RORCFUCA1S1PR1S1PR5 | |
| SCHEMBL1713769 | 0.85 | SIGMAR1 (0.47) | CCR5RORCFUCA1S1PR1S1PR5 | |
| SCHEMBL7868383 | 0.85 | CCR5 (0.42) | CCR5RORCFUCA1S1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351711-B2 | Tricyclic indanyls as integrin inhibitors | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2008-04-01 | — | — | US | disclosed |