Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.48 |
| ▸ | BCR | P11274 | 15/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | PRKCA | P17252 | 9/20 | 0.47 |
| ▸ | SRC | P12931 | 9/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | PRKACB | P22694 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224139 | 0.86 | ABL1 (0.63) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14224448 | 0.78 | KIT (0.54) | ABL1BCRGSK3BPRKCASRC | |
| SCHEMBL14224137 | 0.78 | ABL1 (0.66) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14196033 | 0.78 | ABL1 (0.54) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL13924611 | 0.76 | SYK (0.63) | CDK4CDK2GSK3BSRC | |
| SCHEMBL14196037 | 0.75 | ABL1 (0.64) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14224452 | 0.75 | ABL1 (0.50) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14195964 | 0.75 | ABL1 (0.56) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14224269 | 0.75 | ABL1 (0.51) | ABL1BCRCDK4CDK2GSK3B | |
| SCHEMBL14196032 | 0.74 | ABL1 (0.56) | ABL1BCRPRKCASRCPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |