Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14197101 | 0.90 | FNTA (0.48) | FNTAFNTBEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL14224488 | 0.83 | FNTA (0.40) | FNTAFNTBSMN1; SMN2ALDH1A1CA1 | |
| SCHEMBL14197096 | 0.81 | GAA (0.39) | FNTAFNTBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL14224778 | 0.71 | TSHR (0.43) | ALDH1A1CA1CA2CA12CA3 | |
| SCHEMBL14197187 | 0.69 | TSHR (0.42) | SMN1; SMN2ALDH1A1CA1CA2CA12 | |
| SCHEMBL7356728 | 0.68 | CA12 (0.72) | FNTAFNTBSMN1; SMN2ALDH1A1CA1 | |
| SCHEMBL22060054 | 0.68 | EPHX2 (0.63) | EPHX2NR1H4SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL14224777 | 0.67 | GAA (0.49) | SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL14197089 | 0.66 | GAA (0.48) | SMN1; SMN2LMNAALDH1A1HTTKMT2A | |
| SCHEMBL13299209 | 0.66 | KDM4E (0.63) | FNTAFNTBSMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354919-B2 | Isoxazole compositions useful as inhibitors of ERK | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-08 | — | — | US | disclosed |