Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31117902 | 0.88 | KMT2A (0.51) | KMT2AMEN1LMNAALDH1A1HSD17B10 | |
| SCHEMBL14197223 | 0.82 | MEN1 (0.50) | KMT2AMEN1LMNAALDH1A1HSD17B10 | |
| SCHEMBL31118051 | 0.80 | LTB4R2 (0.44) | KMT2AMEN1LMNAALDH1A1HSD17B10 | |
| SCHEMBL13434089 | 0.79 | KMT2A (0.77) | KMT2AMEN1LMNAALDH1A1HSD17B10 | |
| SCHEMBL1335409 | 0.76 | CYP2C9 (0.54) | KMT2AMEN1LMNAHSD17B10KDM4E | |
| SCHEMBL3463258 | 0.74 | ALDH1A1 (0.60) | KMT2AMEN1LMNAALDH1A1HSD17B10 | |
| SCHEMBL14017766 | 0.74 | ADRA2B (0.50) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL13452589 | 0.74 | ADRA2B (0.50) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL18079514 | 0.73 | TSHR (0.50) | KMT2AMEN1LMNAALDH1A1HSD17B10 | |
| SCHEMBL18765554 | 0.73 | TSHR (0.50) | KMT2AMEN1LMNAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354919-B2 | Isoxazole compositions useful as inhibitors of ERK | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-08 | — | — | US | disclosed |