Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.64 |
| ▸ | DRD4 | P21917 | 6/20 | 0.64 |
| ▸ | HTR2A | P28223 | 6/20 | 0.64 |
| ▸ | HTR2C | P28335 | 5/20 | 0.64 |
| ▸ | HRH1 | P35367 | 5/20 | 0.64 |
| ▸ | DRD2 | P14416 | 4/20 | 0.64 |
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | DRD3 | P35462 | 4/20 | 0.64 |
| ▸ | HRH2 | P25021 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5946392 | 0.91 | MEN1 (0.81) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946345 | 0.87 | MEN1 (0.79) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946369 | 0.86 | MEN1 (0.77) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946376 | 0.86 | MEN1 (0.76) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946357 | 0.85 | MEN1 (0.74) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31098210 | 0.85 | HRH4 (0.73) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946431 | 0.84 | MEN1 (0.68) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL5500954 | 0.83 | LMNA (1.00) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL41643 | 0.83 | LMNA (1.00) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL29414130 | 0.83 | LMNA (1.00) | MEN1LMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |