Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25202320 | 0.94 | PDE4B (0.59) | PDE4BUSP30HPGDSHDAC1HDAC2 | |
| SCHEMBL25227116 | 0.93 | PDE4B (0.51) | PDE4BHDAC1HDAC2MAPTHDAC3 | |
| SCHEMBL14225756 | 0.91 | PDE4B (0.53) | PDE4BFPR2USP30HPGDSHDAC1 | |
| SCHEMBL9962347 | 0.91 | PDE4B (0.54) | PDE4BUSP30HPGDSHDAC1HDAC2 | |
| SCHEMBL24793974 | 0.88 | PDE4B (0.53) | PDE4BUSP30HPGDSHDAC1HDAC2 | |
| SCHEMBL2913125 | 0.88 | PDE4B (0.52) | PDE4BHDAC1HDAC2MAPT | |
| SCHEMBL24196363 | 0.87 | PDE4B (0.52) | PDE4BUSP30HPGDSHDAC1HDAC2 | |
| SCHEMBL10206568 | 0.86 | PDE4B (0.64) | PDE4BUSP30 | |
| SCHEMBL30722047 | 0.85 | PDE4B (0.52) | PDE4BFPR2USP30HPGDSJAK2 | |
| SCHEMBL26985243 | 0.85 | PDE4B (0.52) | PDE4BFPR2USP30HPGDSJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029370-B2 | Substituted benzamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20120316165-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316165-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | NPY4R, PER2, NPY1R | PDE4B 596/4885FPR2 3408/4885USP30 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.