Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23846674 | 0.93 | GGPS1 (0.39) | MMP1MMP2MMP3MMP8CA12 | |
| SCHEMBL18388303 | 0.89 | CA12 (0.41) | CA12CA1CA9CA2ALDH1A1 | |
| SCHEMBL14230113 | 0.88 | CA1 (0.40) | MMP1MMP2MMP3MMP8CA12 | |
| SCHEMBL25063454 | 0.88 | KDM4C (0.38) | MMP1MMP2MMP3MMP8CA12 | |
| SCHEMBL14229151 | 0.88 | MMP1 (0.42) | MMP1MMP2MMP3MMP8CA12 | |
| SCHEMBL20168868 | 0.85 | KDM4C (0.40) | CA12CA1CA9CA2ALDH1A1 | |
| SCHEMBL11120897 | 0.85 | KDM4C (0.40) | MMP1MMP2MMP3MMP8CA12 | |
| SCHEMBL4346470 | 0.85 | CA12 (0.50) | MMP1MMP2MMP3MMP8CA12 | |
| SCHEMBL10087929 | 0.85 | CA12 (0.46) | MMP8CA12CA1CA9CA2 | |
| SCHEMBL10901352 | 0.83 | CA1 (0.37) | MMP1MMP2MMP3MMP8CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |