Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14543508 | 0.92 | TP53 (0.51) | LTB4R2TP53F2RHPGDSMN1; SMN2 | |
| SCHEMBL14228940 | 0.88 | TP53 (0.53) | LTB4R2TP53F2RHPGDSMN1; SMN2 | |
| SCHEMBL14200476 | 0.86 | LTB4R2 (0.44) | LTB4R2TP53HPGDSMN1; SMN2GAA | |
| SCHEMBL14228936 | 0.86 | LTB4R2 (0.47) | LTB4R2TP53F2RHPGDSMN1; SMN2 | |
| SCHEMBL14229354 | 0.84 | TP53 (0.49) | LTB4R2TP53F2RHPGDSMN1; SMN2 | |
| SCHEMBL14230184 | 0.84 | LTB4R2 (0.43) | LTB4R2TP53HPGDTACR3GAA | |
| SCHEMBL14229020 | 0.84 | ALDH1A1 (0.49) | LTB4R2TP53HPGDSMN1; SMN2MEN1 | |
| SCHEMBL14229687 | 0.83 | TP53 (0.40) | LTB4R2TP53L3MBTL1CNR2 | |
| SCHEMBL14229162 | 0.83 | TP53 (0.50) | LTB4R2TP53F2RHPGDSMN1; SMN2 | |
| SCHEMBL14229144 | 0.83 | ALDH1A1 (0.45) | LTB4R2TP53HPGDSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |