Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.45 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229354 | 0.91 | TP53 (0.49) | TP53LTB4R2F2RSMN1; SMN2HPGD | |
| SCHEMBL14228940 | 0.89 | TP53 (0.53) | TP53LTB4R2F2RSMN1; SMN2HPGD | |
| SCHEMBL14228936 | 0.87 | LTB4R2 (0.47) | TP53LTB4R2F2RSMN1; SMN2HPGD | |
| SCHEMBL14543508 | 0.85 | TP53 (0.51) | TP53LTB4R2F2RSMN1; SMN2HPGD | |
| SCHEMBL14200490 | 0.84 | LTB4R2 (0.38) | TP53LTB4R2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14229029 | 0.83 | MEN1 (0.45) | TP53LTB4R2SMN1; SMN2HPGDMEN1 | |
| SCHEMBL14229153 | 0.83 | LTB4R2 (0.49) | TP53LTB4R2F2RSMN1; SMN2HPGD | |
| SCHEMBL14229073 | 0.82 | L3MBTL1 (0.41) | TP53SMN1; SMN2L3MBTL1ALDH1A1LMNA | |
| SCHEMBL14229025 | 0.82 | ALDH1A1 (0.42) | TP53LTB4R2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL14229381 | 0.82 | TP53 (0.41) | TP53L3MBTL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |