Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GPX4 | P36969 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229243 | 0.91 | TP53 (0.56) | TP53MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL2085399 | 0.84 | MTNR1A (0.49) | TP53MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL14200998 | 0.84 | MTNR1A (0.41) | TP53MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL22350387 | 0.82 | TP53 (0.47) | TP53MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL28746541 | 0.81 | EGFR (0.48) | TP53MTNR1AMTNR1BALDH1A1MEN1 | |
| SCHEMBL14230004 | 0.80 | TP53 (0.89) | TP53NPC1RAB9APAX8ALDH1A1 | |
| SCHEMBL11170723 | 0.80 | TP53 (0.45) | TP53MTNR1AMTNR1BRAB9AALDH1A1 | |
| SCHEMBL9593539 | 0.79 | MTNR1A (0.45) | TP53MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL14229452 | 0.78 | TP53 (0.50) | TP53NPC1RAB9APAX8ALDH1A1 | |
| SCHEMBL14229412 | 0.78 | L3MBTL1 (0.43) | TP53MTNR1AMTNR1BRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |