Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GPX4 | P36969 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229221 | 0.89 | TP53 (0.35) | TP53HTTNPSR1TSPOLMNA | |
| SCHEMBL14229509 | 0.87 | TP53 (0.40) | TP53HTTNPSR1TSPOLMNA | |
| SCHEMBL14228964 | 0.85 | TP53 (0.37) | TP53HTTNPSR1TSPOLMNA | |
| SCHEMBL14543550 | 0.85 | TP53 (0.36) | TP53TSPOLMNANPC1ALDH1A1 | |
| SCHEMBL14229029 | 0.85 | MEN1 (0.45) | TP53HTTLMNAMEN1KMT2A | |
| SCHEMBL14200772 | 0.81 | HTT (0.34) | HTTNPSR1TSPOMEN1KMT2A | |
| SCHEMBL14229405 | 0.81 | TP53 (0.36) | TP53HTTNPSR1TSPOLMNA | |
| SCHEMBL14230167 | 0.78 | TP53 (0.35) | TP53HTTNPSR1TSPOMEN1 | |
| SCHEMBL14229554 | 0.77 | MEN1 (0.35) | TP53LMNAMEN1KMT2ANPC1 | |
| SCHEMBL14228985 | 0.77 | KMT2A (0.36) | TP53LMNAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |