Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229510 | 0.91 | MEN1 (0.34) | MEN1KMT2ATP53SMN1; SMN2CYP1A2 | |
| SCHEMBL14229429 | 0.89 | TP53 (0.36) | MEN1KMT2ATP53SMN1; SMN2CYP1A2 | |
| SCHEMBL14229889 | 0.87 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL14229219 | 0.86 | MEN1 (0.35) | MEN1KMT2ATP53 | |
| SCHEMBL14229265 | 0.85 | CYP1A2 (0.39) | MEN1KMT2ATP53CYP1A2CYP2C19 | |
| SCHEMBL14229031 | 0.85 | ALDH1A1 (0.44) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL14543580 | 0.85 | TP53 (0.35) | MEN1KMT2ATP53SMN1; SMN2CYP1A2 | |
| SCHEMBL14200889 | 0.84 | HDAC8 (0.33) | — | |
| SCHEMBL14228985 | 0.84 | KMT2A (0.36) | MEN1KMT2ATP53SMN1; SMN2CYP1A2 | |
| SCHEMBL14229224 | 0.83 | LTB4R2 (0.33) | MEN1KMT2ATP53SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |