Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSPO | P30536 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GPX4 | P36969 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230167 | 0.91 | TP53 (0.35) | TP53MEN1KMT2ATSPOHTT | |
| SCHEMBL14228964 | 0.89 | TP53 (0.37) | TP53MEN1KMT2ATSPOHTT | |
| SCHEMBL14229531 | 0.86 | TAS1R3 (0.47) | TP53TAS1R3TAS1R1MEN1KMT2A | |
| SCHEMBL14229221 | 0.86 | TP53 (0.35) | TP53TAS1R3TAS1R1MEN1KMT2A | |
| SCHEMBL14229509 | 0.83 | TP53 (0.40) | TP53MEN1KMT2ATSPOHTT | |
| SCHEMBL14200832 | 0.83 | TAS1R3 (0.32) | TP53TAS1R3TAS1R1MEN1KMT2A | |
| SCHEMBL14229283 | 0.81 | TP53 (0.36) | TP53MEN1KMT2ATSPOHTT | |
| SCHEMBL14543550 | 0.79 | TP53 (0.36) | TP53TSPOLMNANPC1ALDH1A1 | |
| SCHEMBL14229297 | 0.78 | KMT2A (0.37) | TP53MEN1KMT2ALMNANPC1 | |
| SCHEMBL14543580 | 0.78 | TP53 (0.35) | TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |