Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229166 | 0.94 | KCNH2 (0.37) | KCNH2LMNACRHR1DYRK1A | |
| SCHEMBL14229636 | 0.90 | CRHR1 (0.33) | KCNH2KDM4ELMNACYP3A4TSHR | |
| SCHEMBL14229039 | 0.90 | KCNH2 (0.33) | KCNH2KDM4ELMNACYP3A4TSHR | |
| SCHEMBL14229717 | 0.90 | CRHR1 (0.32) | CRHR1DYRK1A | |
| SCHEMBL14229183 | 0.87 | KCNH2 (0.33) | KCNH2KDM4ELMNACYP3A4TSHR | |
| SCHEMBL14200641 | 0.85 | ACACB (0.30) | KDM4ELMNACYP3A4TSHR | |
| SCHEMBL14228953 | 0.84 | KCNH2 (0.36) | KCNH2LMNA | |
| SCHEMBL14229634 | 0.84 | KCNH2 (0.36) | KCNH2LMNATSHRCRHR1 | |
| SCHEMBL14229382 | 0.83 | KCNH2 (0.32) | KCNH2KDM4ELMNACYP3A4TSHR | |
| SCHEMBL14229495 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |