Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.56 |
| ▸ | RAB9A | P51151 | 12/20 | 0.56 |
| ▸ | TP53 | P04637 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.49 |
| ▸ | RELA | Q04206 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13417025 | 0.83 | NPC1 (0.69) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL29936956 | 0.79 | NPC1 (0.57) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL1421288 | 0.79 | NPC1 (0.55) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL3678372 | 0.77 | CHRNB2 (0.52) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL12171461 | 0.76 | NPC1 (0.57) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL16592598 | 0.74 | NR1H4 (0.58) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL3672498 | 0.73 | LMNA (0.47) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL3672500 | 0.73 | LMNA (0.47) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL1423193 | 0.72 | CHRNB2 (0.83) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL1421528 | 0.72 | CHRNB2 (0.72) | NPC1RAB9ATP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297140-A1 | NOVEL 1,2,4 OXADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | claimed |
| EP-2297140-A1 | NOVEL 1,2,4 OXADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |