Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021224 | 0.85 | MAPT (0.66) | MAPTGAAALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL5468425 | 0.81 | MAPT (0.74) | MAPTGAAALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL10144139 | 0.81 | MAPT (0.67) | MAPTGAAALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL25787603 | 0.81 | MAPT (0.61) | MAPTGAAALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL1422991 | 0.79 | ADRB1 (0.81) | MAPTGAAALDH1A1GFERHTT | |
| SCHEMBL5543934 | 0.78 | MAPT (0.68) | MAPTGAAALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL25447362 | 0.77 | MAPT (0.60) | MAPTGAAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL8320341 | 0.77 | ADRB1 (0.61) | MAPTGAAALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL8695578 | 0.75 | AKR1C3 (0.65) | MAPTGAAALDH1A1GFERHTT | |
| SCHEMBL19059406 | 0.75 | TDP1 (0.62) | MAPTGAAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102214-B1 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-03-23 | — | — | EP | disclosed |
| EP-2102214-A1 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| US-7557101-B2 | 4,5,6,7-tetrahydro-thieno[3,2-c] pyridine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-07-07 | — | — | US | disclosed |
| WO-2008068173-A9 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-06-25 | — | — | WO | disclosed |
| US-20080146558-A1 | 4,5,6,7-Tetrahydro-Thieno [3,2-C] Pyridine Derivatives | HOFFMANN-LA ROCHE, INC. | 2008-06-19 | — | — | US | disclosed |
| WO-2008068173-A1 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146558-A1 | 4,5,6,7-Tetrahydro-Thieno [3,2-C] Pyridine Derivatives | HRH4, HRH3, HRH2 | MAPT 2444/4885GAA 3493/4885ALDH1A1 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.