Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.70 |
| ▸ | PRKCQ | Q04759 | 8/20 | 0.70 |
| ▸ | KDR | P35968 | 6/20 | 0.69 |
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.69 |
| ▸ | JAK2 | O60674 | 3/20 | 0.69 |
| ▸ | ABL1 | P00519 | 3/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.69 |
| ▸ | LCK | P06239 | 3/20 | 0.69 |
| ▸ | LYN | P07948 | 3/20 | 0.69 |
| ▸ | RET | P07949 | 3/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.69 |
| ▸ | KIT | P10721 | 3/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.69 |
| ▸ | CDK4 | P11802 | 3/20 | 0.69 |
| ▸ | SRC | P12931 | 3/20 | 0.69 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.69 |
| ▸ | CCND1 | P24385 | 3/20 | 0.69 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.69 |
| ▸ | CDK2 | P24941 | 3/20 | 0.69 |
| ▸ | FLT3 | P36888 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20609293 | 0.83 | PRKCQ (0.65) | ROCK2PRKCQKDRMAP3K5JAK2 | |
| SCHEMBL12570349 | 0.82 | PRKCQ (0.85) | ROCK2PRKCQKDRMAP3K5PRKCA | |
| SCHEMBL12570608 | 0.82 | PRKCQ (0.85) | ROCK2PRKCQKDRMAP3K5PRKCA | |
| SCHEMBL12570606 | 0.82 | PRKCQ (0.85) | ROCK2PRKCQKDRMAP3K5PRKCA | |
| SCHEMBL24606232 | 0.82 | PRKCZ (1.00) | ROCK2PRKCQKDRMAP3K5JAK2 | |
| SCHEMBL18808417 | 0.82 | PRKCZ (1.00) | ROCK2PRKCQKDRMAP3K5JAK2 | |
| SCHEMBL20333841 | 0.82 | PRKCZ (1.00) | ROCK2PRKCQKDRMAP3K5JAK2 | |
| SCHEMBL14845612 | 0.82 | PRKCZ (1.00) | ROCK2PRKCQKDRMAP3K5JAK2 | |
| SCHEMBL19050325 | 0.81 | PRKCQ (0.75) | ROCK2PRKCQKDRMAP3K5PRKCA | |
| SCHEMBL30885079 | 0.81 | PRKCQ (1.00) | ROCK2PRKCQKDRMAP3K5PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081078-A1 | Prevention of Cell Proliferation by Inhibiting Myosin Light Chain Kinase | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081078-A1 | Prevention of Cell Proliferation by Inhibiting Myosin Light Chain Kinase | MYLK3, MYLK, MYLK4 | ROCK2 50/4885PRKCQ 379/4885KDR 2749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.