Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.72 |
| ▸ | MEN1 | O00255 | 9/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.72 |
| ▸ | HPGD | P15428 | 6/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.72 |
| ▸ | TP53 | P04637 | 5/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | USP2 | O75604 | 2/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.62 |
| ▸ | CA12 | O43570 | 3/20 | 0.62 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | AR | P10275 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29432477 | 0.84 | MEN1 (1.00) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL7369044 | 0.84 | MEN1 (0.50) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL290081 | 0.84 | MEN1 (1.00) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL27708510 | 0.83 | CYP3A4 (0.74) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL29465830 | 0.81 | MEN1 (0.72) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL15676525 | 0.81 | CYP3A4 (0.72) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5128375 | 0.81 | MEN1 (0.72) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL9400245 | 0.81 | CYP3A4 (0.72) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| SCHEMBL10514558 | 0.81 | MEN1 (0.62) | CYP3A4KDM4EMEN1KMT2AMAPT | |
| Phosphoric Acid SCHEMBL3659763 | 0.79 | MEN1 (0.88) | CYP3A4KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144194-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AXOGLIA THERAPEUTICS (LU) | 2011-06-16 | — | — | US | disclosed |
| EP-2297127-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AxoGlia Therapeutics S.A. (LU) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009130253-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AXOGLIA THERAPEUTICS S.A. (LU) | 2009-10-29 | — | — | WO | disclosed |
| EP-2112145-A1 | Chromenone derivatives useful for the treatment of neurodegenerative diseases | AxoGlia Therapeutics S.A. (LU) | 2009-10-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144194-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PARK7, CDR2, SNCA | CYP3A4 1013/4885KDM4E 2608/4885MEN1 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.