Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423156 | 0.84 | CYP3A4 (0.72) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL29501080 | 0.79 | KMT2A (0.65) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL1534666 | 0.79 | KMT2A (0.65) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL27839378 | 0.77 | CA1 (0.41) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL28227307 | 0.74 | MAPK8 (0.56) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL21585300 | 0.72 | MAOA (0.63) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL6825859 | 0.71 | KMT2A (0.53) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL27940011 | 0.69 | KDM4E (0.60) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL1534415 | 0.69 | DDR2 (0.51) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL27952154 | 0.69 | CYP3A4 (0.74) | MEN1KMT2ACYP3A4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714296-B1 | FLAVONOID AND BIFLAVONOID DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR ANXIOLYTIC ACTIVITY | UNIV STRATHCLYDE (GB) | 2001-11-07 | — | — | EP | disclosed |
| EP-0973516-A1 | USE OF HALO AND/OR NITRO-SUBSTITUTED FLAVONOIDS AS ANXYOLITICS | University of Strathclyde (GB) | 2000-01-26 | — | — | EP | disclosed |
| US-6004998-A | FLAVONOID 6,8-DIBROMOCHRYSIN | UNIVERSITY OF STRATHCLYDE (GB) | 1999-12-21 | — | — | US | disclosed |
| WO-1998044920-A1 | USE OF HALO AND/OR NITRO-SUBSTITUTED FLAVONOIDS AS ANXYOLITICS | UNIVERSITY OF STRATHCLYDE (GB) | 1998-10-15 | — | — | WO | disclosed |
| US-5756538-A | REDUCING THE SEDATIVE AND RELAXANT SIDE EFFECT | UNIVERSITY OF STRATHCLYDE (GB) | 1998-05-26 | — | — | US | disclosed |
| EP-0714296-A1 | FLAVONOID AND BIFLAVONOID DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR ANXIOLYTIC ACTIVITY | UNIVERSITY OF STRATHCLYDE (GB) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005169-A1 | FLAVONOID AND BIFLAVONOID DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR ANXIOLYTIC ACTIVITY | THE UNIVERSITY OF STRATHCLYDE (GB) | 1995-02-23 | — | — | WO | disclosed |