Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 17/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423066 | 0.87 | NPC1 (0.44) | ACLYHTR6NPC1HTTRAB9A | |
| SCHEMBL1423370 | 0.86 | ACLY (0.53) | ACLYHTR6NPC1HTTRAB9A | |
| SCHEMBL1423218 | 0.77 | ACLY (0.54) | ACLYHTR6CCKBRHTR2C | |
| SCHEMBL1422633 | 0.76 | ACLY (0.58) | ACLYHTR6CCKBRHTR2C | |
| SCHEMBL1575956 | 0.76 | HTR6 (0.69) | ACLYHTR6NPC1HTTRAB9A | |
| SCHEMBL3156457 | 0.76 | HTR6 (0.69) | ACLYHTR6NPC1HTTRAB9A | |
| SCHEMBL1591407 | 0.76 | HTR6 (0.57) | ACLYHTR6NPC1HTTRAB9A | |
| SCHEMBL1880552 | 0.75 | ACLY (0.52) | ACLYHTR6CCKBRCYP3A4CYP2A6 | |
| SCHEMBL2003128 | 0.74 | HTR6 (0.80) | HTR6NPC1HTTRAB9ACYP3A4 | |
| SCHEMBL17599323 | 0.74 | ACLY (0.63) | ACLYHTR6CCKBRHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297166-A1 | SUBSTITUTED N-IMIDAZO[2,1-B]THIAZOLE-5-SULFONAMIDE DERIVATIVES AS 5-HT6 LIGANDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-03-23 | — | — | EP | claimed |