Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14235390 | 0.89 | HCAR3 (0.48) | HCAR3ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL14236011 | 0.86 | HCAR3 (0.35) | HCAR3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL14235364 | 0.79 | HCAR3 (0.50) | HCAR3ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL14235819 | 0.73 | HCAR3 (0.51) | HCAR3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL14235840 | 0.71 | HCAR3 (0.50) | HCAR3ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL14235599 | 0.70 | HCAR3 (0.55) | HCAR3ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL14213417 | 0.70 | HCAR3 (0.54) | HCAR3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL14235839 | 0.69 | HCAR3 (0.48) | HCAR3HCAR2ALPLMAOBGAA | |
| SCHEMBL14213420 | 0.69 | HCAR3 (0.50) | HCAR3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL14213418 | 0.69 | HCAR3 (0.50) | HCAR3PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309773-A1 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309773-A1 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | JAK2, JAK1, JAK3 | HCAR3 2267/4885PRKAB2 645/4885PRKAG1 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.