Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.39 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.39 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5075232 | 0.80 | CHUK (0.42) | IRAK4GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL5078760 | 0.80 | CHUK (0.42) | IRAK4GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL5075238 | 0.80 | CHUK (0.42) | IRAK4GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL5635477 | 0.70 | PIM1 (0.41) | ADORA2A | |
| SCHEMBL5635759 | 0.70 | PIM1 (0.41) | ADORA2A | |
| SCHEMBL13723671 | 0.67 | GUCY1B2 (0.45) | IRAK4GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL19325285 | 0.65 | TLR9 (0.37) | NTRK1TLR9TLR8TLR7 | |
| SCHEMBL19684530 | 0.62 | NTRK1 (0.40) | NTRK1 | |
| SCHEMBL17776870 | 0.61 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL19258011 | 0.60 | NTRK1 (0.34) | NTRK1TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532667-A1 | Deazapurines useful as inhibitors of janus kinases | Vertex Pharmaceuticals Incorporated (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-1931674-B1 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMA (US) | 2012-12-12 | — | — | EP | disclosed |