Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRND | Q07001 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL14237153 | 0.85 | CCR2 (0.57) | CCR2SLC6A2SLC6A3CHRNA1CHRNG | |
| Bicarbonate SCHEMBL14237102 | 0.84 | CCR2 (0.58) | CCR2SLC6A2SLC6A4SLC6A3CHRNA1 | |
| SCHEMBL28842376 | 0.81 | CCR2 (0.45) | CCR2 | |
| Bicarbonate SCHEMBL14237114 | 0.81 | CCR2 (0.61) | CCR2 | |
| Bicarbonate SCHEMBL14237258 | 0.78 | CCR2 (0.56) | CCR2 | |
| Bicarbonate SCHEMBL14237131 | 0.76 | CCR2 (0.54) | CCR2 | |
| Bicarbonate SCHEMBL14237079 | 0.75 | CCR2 (0.47) | CCR2KMO | |
| Bicarbonate SCHEMBL14237166 | 0.75 | CCR2 (0.46) | CCR2 | |
| Bicarbonate SCHEMBL14237273 | 0.75 | CCR2 (0.55) | CCR2 | |
| SCHEMBL1780947 | 0.74 | CCR2 (1.00) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318352-B1 | CYCLOHEXENYL COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |