Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
| ▸ | LDHB | P07195 | 1/20 | 0.57 |
| ▸ | ATR | Q13535 | 18/20 | 0.52 |
| ▸ | PRKDC | P78527 | 6/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237367 | 0.83 | LDHA (0.60) | LDHALDHBATRPRKDCATM | |
| SCHEMBL14237502 | 0.83 | ACVR2A (0.55) | LDHALDHBATRPRKDCACVR1 | |
| SCHEMBL3460516 | 0.77 | ATR (0.70) | LDHALDHBATRPRKDCACVR1 | |
| SCHEMBL3462214 | 0.74 | ACVR1 (0.61) | ATRPRKDCACVR1ATM | |
| SCHEMBL3460485 | 0.72 | ACVR1 (0.61) | ATRPRKDCACVR1ATM | |
| SCHEMBL3460037 | 0.71 | ACVR1 (0.57) | ATRPRKDCACVR1 | |
| SCHEMBL3461134 | 0.71 | ACVR1 (0.63) | ATRPRKDCACVR1ATM | |
| SCHEMBL3460825 | 0.70 | ATR (0.58) | LDHALDHBATRPRKDCACVR1 | |
| SCHEMBL17434318 | 0.70 | ATR (0.56) | ATRPRKDCACVR1 | |
| SCHEMBL11909154 | 0.69 | ATR (0.72) | LDHALDHBATRPRKDCATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | claimed |