Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.37 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237587 | 0.92 | TDP1 (0.36) | TDP1NQO1ALDH1A1HTTLMNA | |
| SCHEMBL14237632 | 0.90 | TDP1 (0.37) | TDP1NQO1ALDH1A1HTTLMNA | |
| SCHEMBL2129981 | 0.88 | SLC6A5 (0.38) | TDP1NQO1ALDH1A1HTTLMNA | |
| SCHEMBL2130106 | 0.82 | ALDH1A1 (0.36) | TDP1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL1726191 | 0.80 | TDP1 (0.37) | TDP1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL1724918 | 0.79 | SLC6A5 (0.41) | TDP1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL2601747 | 0.76 | RAD52 (0.42) | TDP1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL2601755 | 0.75 | ALDH1A1 (0.45) | NQO1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL2601754 | 0.75 | ALDH1A1 (0.45) | TDP1NQO1ALDH1A1HTTLMNA | |
| SCHEMBL2601756 | 0.74 | ALDH1A1 (0.44) | TDP1NQO1ALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403856-B1 | METHYLENEDIOXYBENZO [I]PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER | UNIV RUTGERS (US) | 2012-12-19 | — | — | EP | claimed |