SCHEMBL14237665

SCHEMBL14237665

O=C(O)CCCCCON1C(=O)c2ccccc2C1=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.56
ALDH1A1 P00352 4/20 0.53
CYP1A2 P05177 2/20 0.53
CYP2C9 P11712 1/20 0.53
RECQL P46063 1/20 0.51
PPARG P37231 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
MAPT P10636 1/20 0.45
RXFP1 Q9HBX9 1/20 0.45
CA12 O43570 1/20 0.45
CA9 Q16790 1/20 0.45
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18262805 0.94 GAA (0.59) GAAALDH1A1CYP1A2CYP2C9RECQL
SCHEMBL24507059 0.87 GAA (0.71) GAAALDH1A1CYP1A2CYP2C9RECQL
SCHEMBL1532004 0.85 PPARG (0.45) GAAALDH1A1CYP1A2CYP2C9PPARG
SCHEMBL26480 0.85 PPARG (0.45) GAAALDH1A1CYP1A2CYP2C9PPARG
SCHEMBL1532120 0.83 PPARG (0.46) GAAALDH1A1CYP1A2CYP2C9PPARG
SCHEMBL12728222 0.82 ALDH1A1 (0.51) GAAALDH1A1CYP1A2CYP2C9RECQL
SCHEMBL12290505 0.82 GAA (0.50) GAAALDH1A1CYP1A2CYP2C9RECQL
SCHEMBL12244739 0.82 GAA (0.61) GAAALDH1A1CYP1A2CYP2C9RECQL
SCHEMBL14237856 0.81 GAA (0.75) GAAALDH1A1CYP1A2CYP2C9RECQL
SCHEMBL29475643 0.81 GAA (0.75) GAAALDH1A1CYP1A2CYP2C9RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12037405-B2 Anti-CD70 antibody drug conjugates AMBRX, INC. 2024-07-16 US disclosed
US-12037405-B2 Anti-CD70 antibody drug conjugates AMBRX, INC. 2024-07-16 US disclosed
US-20230295320-A1 Anti-CD70 Antibody Drug Conjugates AMBRX, INC. (US) 2023-09-21 US disclosed
US-20230295320-A1 Anti-CD70 Antibody Drug Conjugates AMBRX, INC. (US) 2023-09-21 US disclosed
US-20220033518-A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATES AMBRX,INC. (US) 2022-02-03 US disclosed
US-20210277056-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES AMBRX, INC. (US) 2021-09-09 US disclosed
US-10954270-B2 Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives AMBRX, INC. (US) 2021-03-23 US disclosed
US-10800856-B2 Prostate-specific membrane antigen antibody drug conjugates AMBRX, INC. (US) 2020-10-13 US disclosed
EP-3536700-A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATES Ambrx, Inc. (US) 2019-09-11 EP disclosed
US-10208123-B2 Anti-CD70 antibody drug conjugates AMBRX, INC. (US) 2019-02-19 US disclosed
US-10093621-B2 4-oxo-N-(4-hydroxyphenyl)retinamide derivatives as therapeutic agents for the treatment of cancer FONDAZIONE IRCCS INSTITUTO NAZIONALE DEI TUMORI (IT) 2018-10-09 US disclosed
EP-3194360-B1 4-OXO-N-(4-HYDROXYPHENYL)RETINAMIDE DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER FONDAZIONE IRCCS ISTITUTO NAZ DEI TUMORI (IT) 2018-06-27 EP disclosed
US-9796754-B2 Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives AMBRX, INC. (US) 2017-10-24 US disclosed
US-20170253560-A1 4-OXO-N-(4-HYDROXYPHENYL)RETINAMIDE DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (IT) 2017-09-07 US disclosed
US-20170253560-A1 4-OXO-N-(4-HYDROXYPHENYL)RETINAMIDE DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (IT) 2017-09-07 US disclosed
US-20150152190-A1 Prostate-Specific Membrane Antigen Antibody Drug Conjugates AMBRX, INC. (US) 2015-06-04 US disclosed
US-20150152190-A1 Prostate-Specific Membrane Antigen Antibody Drug Conjugates AMBRX, INC. (US) 2015-06-04 US disclosed
US-20150141624-A1 Anti-CD70 Antibody Drug Conjugates AMBRX, INC. (US) 2015-05-21 US disclosed
US-20150141624-A1 Anti-CD70 Antibody Drug Conjugates AMBRX, INC. (US) 2015-05-21 US disclosed
WO-2012166560-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES AMBRX, INC. (US) 2012-12-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12037405-B2 Anti-CD70 antibody drug conjugates CD74, CD63, CD47 GAA 438/4885ALDH1A1 868/4885CYP1A2 2119/4885
US-20150141624-A1 Anti-CD70 Antibody Drug Conjugates CD74, CD63, CD47 GAA 438/4885ALDH1A1 868/4885CYP1A2 2119/4885
US-10093621-B2 4-oxo-N-(4-hydroxyphenyl)retinamide derivatives as therapeutic agents for the treatment of cancer ALDH1A2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RB1 GAA 4467/4885ALDH1A1 152/4885CYP1A2 2936/4885
US-10208123-B2 Anti-CD70 antibody drug conjugates CD74, CD63, CD47 GAA 438/4885ALDH1A1 868/4885CYP1A2 2119/4885
US-10800856-B2 Prostate-specific membrane antigen antibody drug conjugates KLK3, PTMS, DDOST GAA 557/4885ALDH1A1 2041/4885CYP1A2 3716/4885
US-20210277056-A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES DDOST, DAD1, PTMS GAA 2037/4885ALDH1A1 4288/4885CYP1A2 4085/4885
US-10954270-B2 Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives DDOST, DAD1, PTMS GAA 2037/4885ALDH1A1 4288/4885CYP1A2 4085/4885
US-20170253560-A1 4-OXO-N-(4-HYDROXYPHENYL)RETINAMIDE DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER ALDH1A2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RB1 GAA 4467/4885ALDH1A1 152/4885CYP1A2 2936/4885
US-20230295320-A1 Anti-CD70 Antibody Drug Conjugates CD63, CD74, CD99 GAA 529/4885ALDH1A1 1177/4885CYP1A2 2172/4885
US-20220033518-A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATES KLK3, PTMS, DDOST GAA 557/4885ALDH1A1 2041/4885CYP1A2 3716/4885
US-20150152190-A1 Prostate-Specific Membrane Antigen Antibody Drug Conjugates KLK3, PTMS, DDOST GAA 557/4885ALDH1A1 2041/4885CYP1A2 3716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.